Acceptability of medicines in children and caregivers affects safety and effectiveness of medicinal treatments. The pharmaceutical industry is required to demonstrate acceptability of new paediatric formulations in target age groups as an integrated part of the development of these products (Kozarewicz, 2014). Two questions arise when trying to tackle this task: “which dosage form to choose for each target age group?” and “how to formulate it once the dosage form is decided?”. Inevitably, both the regulator and the developer turn to scientific evidence for answers. Research has emerged in recent years to demonstrate age-appropriateness and patient acceptability of different dosage forms; however, such information is still fragmented and far from satisfactory to define efficient formulation development strategies for a diverse patient subset (Ranmal and Tuleu, 2013). This paper highlights how formulation factors affect the acceptability of different oral medicines in children (Table 1), and it is based on a more extensive review article by Liu et al. (Liu et al., 2014). Gaps in knowledge are highlighted in order to stimulate further research. In some areas, findings from studies conducted in adult populations may provide useful guidance for paediatric development and this is also discussed.
Formulation factors affecting acceptability of oral medicines in children – ScienceDirect
-
Maximizing Roller Compaction Benefits with Proper Excipient Selection
Pharma Live, , Formulation Discussion, 0
The pharmaceutical industry has adopted roller compaction due to its significant advantage in production process efficiency and its applicability...
-
Observations on Nanotechnology-based Drug Delivery Approaches: Translating Nanotechnology from Bench to Pharmaceutical Market: Barriers, Success, and Promises
Pharma Live, , Formulation Discussion, 0
David Fairhurst, Ph.D. Robert W. Lee, Ph.D. Particle Sciences, Inc., 3894 Courtney Street, Bethlehem, PA 18017 Introduction To stay...
-
Microbially triggered drug delivery to the colon
Pharma Live, , Formulation Discussion, 0
1-s2-0-s092809870200221x-mainDownload
-
Increasing Manufacturing Efficiencies in Capsule Filling Systems – Courtesy (Pharmaceutical Onine)
Pharma Live, , Formulation Discussion, 0
Almost every capsule filling machine on the market is capable of dosing the full range of fill media including...
-
Improvement of the stability of doxycycline hydrochloride pellet-containing tablets through a novel granulation technique and proper excipients
Pharma Live, , Formulation Discussion, 0
1-s2-0-s0032591014008730-mainDownload
-
Impact of compression pressure on tablet appearance – Science Direct
Pharma Live, , Formulation Discussion, 0
The color of model tablets deepened and tablet gloss increased with increase in compression pressure regardless of colorant type....
-
Patient-centered drug discovery as the means to improved R&D productivity
Pharma Live, , Formulation Discussion, 0
1-s2-0-s1359644615001464-mainDownload
-
ORAL CONTROLLED RELEASE DRUG DELIVERY SYSTEM- A REVIEW
Pharma Live, , Formulation Discussion, 0
ABOUT AUTHORS:Manisha Gahlyan*, Saroj JainHindu college of pharmacyNear Panchayat Bhawan, Gohana Road, Sonepat, [email protected] ABSTRACT:Oral route has been the...
![](https://ml7mn4k5dnn0.i.optimole.com/w:289/h:289/q:eco/f:best/https://interactivepharm.com/wp-content/uploads/2022/08/Show-your.jpg)